| Application Dept. |
Graduate Institute of Biomedical Sciences |
| Principal Investigator |
Prof. Meei-Ling Sheu ( Personal Webpage ) |
| Project Title |
Preclinical study of proliferative diabetic retinopathy hypoxia-induced morphological, biomechanical, and compositional changes in erythrocytes and retinal endothelial cells |
| Co-Principal Investigator |
1. Prof. Mon-Shu Ho, Dept. of Physics 2. Prof. Maw-Rong Lee, Dept. of Chemistry |
| Co-Investigator |
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| Abstract |
Diabetic retinopathy (DR) is one of an important microvascular complication of diabetes which result in blindness in the proportion of the working age population found predominantly in the developed world [1]. The progression pathogenesis of DR is multifactorial involving the interplay of genetic environmental factors, but is primarily caused by the metabolic effects of chronic hyperglycemia associated with long-term damage, which leads to result in vascular dysfunction or changes resulting in retinal ischemia. Relevance to main project: This study was conducted to determine the role of N-carboxymethyl-Lysine (CML) in these diabetic complications. This knowledge is leading to identification of new targets therapeutic strategies for preventing vascular leakage, pathologic angiogenesis. These advances, together with approaches embracing the potential of preventative or therapeutic medicine, could provide the means to better manage DR, including treatment at earlier stages more precise tailoring of treatments based on individual patient variations. |
