| 申請系所(單位) |
生物醫學研究所 |
| 計畫主持人 |
許美鈴 教授 ( 個人網頁 ) |
| 計畫名稱(中文) |
臨床前研究探討-增殖性糖尿病視網膜病變缺氧誘導紅細胞和視網膜內皮細胞形態學，生物力學和組成變化 |
| 計畫名稱(英文) |
Preclinical study of proliferative diabetic retinopathy hypoxia-induced morphological, biomechanical, and compositional changes in erythrocytes and retinal endothelial cells |
| 共同主持人 |
1. 何孟書 教授 / 物理學系 2. 李茂榮 教授 / 化學系 |
| 協同主持人 |
1.臺中榮民總醫院新陳代謝科-許惠恒主治醫師兼院長 (本校轉譯醫學學程中心合聘教授) 2.臺中榮民總醫院新陳代謝科-王俊興主治醫師 (本校轉譯醫學學程中心合聘助理教授) 3. 臺中榮民總醫院眼科-林耿弘主治醫師暨主任 (本校轉譯醫學學程中心合聘助理教授) |
| 中文摘要 |
糖尿病視網膜病變（DR）是糖尿病的重要微血管並發症之一，導致發達國家主要發現的工作年齡人口比例失明。 DR的進展和發病機制是多因素的，涉及遺傳和環境因素的相互作用，但主要由慢性高血糖的代謝作用引起並且與長期損傷相關，其導致血管功能障礙或導致視網膜缺血的變化。 實驗研究旨在確定N- 羧甲基賴氨酸（CML）在這些糖尿病並發症中的作用。這些知識將標定新靶點和預防血管滲漏和病理性血管生成的治療策略。這些進步以及包含預防或治療藥物潛力的方法可以提供更好地管理DR的手段與策略，包括早期治療和根據患者個體差異更精確地定制治療方法。 |
| 英文摘要 |
Diabetic retinopathy (DR) is one of an important microvascular complication of diabetes which result in blindness in the proportion of the working age population found predominantly in the developed world [1]. The progression pathogenesis of DR is multifactorial involving the interplay of genetic environmental factors, but is primarily caused by the metabolic effects of chronic hyperglycemia associated with long-term damage, which leads to result in vascular dysfunction or changes resulting in retinal ischemia. Relevance to main project: This study was conducted to determine the role of N-carboxymethyl-Lysine (CML) in these diabetic complications. This knowledge is leading to identification of new targets therapeutic strategies for preventing vascular leakage, pathologic angiogenesis. These advances, together with approaches embracing the potential of preventative or therapeutic medicine, could provide the means to better manage DR, including treatment at earlier stages more precise tailoring of treatments based on individual patient variations. |
